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A novel agonistic antibody to human death receptor 4 induces apoptotic cell death in various tumor cells without cytotoxicity in hepatocytes

✍ Scribed by Sung, E.-S.; Park, K.-J.; Lee, S.-H.; Jang, Y.-S.; Park, S.-K.; Park, Y.-H.; Kwag, W.-J.; Kwon, M.-H.; Kim, Y.-S.


Book ID
118055496
Publisher
American Association for Cancer Research
Year
2009
Tongue
English
Weight
480 KB
Volume
8
Category
Article
ISSN
1535-7163

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## Abstract TRAIL (TNF‐related apoptosis‐inducing ligand) induces apoptosis on binding to DR4 and DR5 receptors on the surface of tumor cells. These receptors are of particular interest in the development of cancer therapeutics as they preferentially mediate tumor cell apoptosis. We have generated