✦ LIBER ✦
A novel acid stable/base labile carbamate linker for N-acyliminium ion reactions on solid support
✍ Scribed by Johan J.N. Veerman; Floris P.J.T. Rutjes; Jan H. van Maarseveen; Henk Hiemstra
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 240 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The development of a novel carbamate linker optimized for solid phase N-acyliminium ion chemistry is reported. Some 2-and 2,4-substituted pyrrolidines were synthesized via addition of several carbon nucleophiles to immobilized N-acyliminium ions. A ~-sulfonylethyl carbamate linker appeared especially useful; readily synthesized, stable towards Lewis acids and easily cleavable.