A novel access to bisformylated pyrroles via decarboxylation of N-aryl-γ-lactam-carboxylic acids under Vilsmeier reaction conditions

✍ Scribed by Gopa Barman; Jayanta K. Ray

• Book ID: 104097131
• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 385 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.11.005

✦ Synopsis

A simple methodology for the conversion of substituted N-aryl-c-lactam 2/3-carboxylic acids to substituted N-aryl-diformylated pyrroles has been developed. Several c-lactam 2/3-carboxylic acids were subjected to Vilsmeier reagent and substituted diformylated pyrroles are isolated in one-step process.