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A note on multinomial maximum likelihood estimation under ordered restrictions and the EM algorithm

โœ Scribed by Yuling Li; Wei Gao; Ning-Zhong Shi

Publisher
Springer
Year
2006
Tongue
English
Weight
134 KB
Volume
66
Category
Article
ISSN
0026-1335

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## Abstract In linkage analysis, estimated recombination fractions between a disease gene and several markers are used to assign the disease gene to a a particular chromosome region. For rare diseases, locus heterogeneity leads to different recombination fractions in different families, and a set o