Substructural fragment occurrence data are widely used as the basis for measures of inter-molecular structural similarity. This paper investigates the effect of standardization on the effectiveness of such measures using eight data sets for which both structural and biological activity data are avai
A note on measures of similarity based on centrality
β Scribed by Soong Moon Kang
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 694 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0378-8733
No coin nor oath required. For personal study only.
β¦ Synopsis
This note presents a measure of similarity between connected nodes in terms of centrality based on Euclidean distances, and compares it to 'assortative mixing' [Newman, M.E.J., 2002. Assortative mixing in networks. Physical Review Letters 89, 208701], which is based on Pearson correlation coefficient. This study suggests that the measure based on Euclidean distances may be more appropriate for relatively smaller (N < 500) and denser networks.
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