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A norbornyl route to some novel seven-membered iminocyclitols
β Scribed by Goverdhan Mehta; Sripada Lakshminath
- Book ID
- 104232165
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 70 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
New hydroxy azepanes with an additional hydroxymethyl side arm have been conceived and their syntheses achieved from a suitably functionalized cyclohexanoid building-block extracted from the norbornyl framework. The new iminocyclitols (homoisofagomine derivatives) exhibit weak but selective inhibitory activity in enzyme assays.
π SIMILAR VOLUMES
A facile method for the construction of bicyclo[6.3.0]undecane or bicyclo-[5.3.0]decane skeleton has been developed by the tandem application of the intramolecular Kulinkovich cyclopropanation of co-vinyl esters and oxidation of the resulting cyclopropanols.
The chemistry of the thionester functional group (-C(=S)OR) has remained relatively dormant. While the recent literature describes a variety of thionating agents, 2 and various ways of synthesizing thionesters, 3 there appears to be no general method for making thionolactones. 4 We herein report on