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A norbornyl route to azasugars: stereoselective synthesis of isofagomine analogues

✍ Scribed by Goverdhan Mehta; Narinder Mohal

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
162 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

A stereoselective synthesis of new isofagomine analogues has been achieved from a suitably functionalized cyclopentene intermediate extracted from the norbornyl framework. Double reductive amination or inter-and intramolecular N-alkylations are the key steps in constructing the piperidine ring. Isofagomine derivatives exhibit moderate inhibitory activity in enzyme assays.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: A Norbornyl Route t
ChemInform Abstract: A Norbornyl Route to Azasugars: Stereoselective Synthesis of Isofagomine Analogues.
✍ Goverdhan Mehta; Narinder Mohal πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons βš– 30 KB πŸ‘ 2 views

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A norbornyl route to cyclohexitols: ster
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A novel fragmentation sequence within the norbornane system, involving C 1 -C 7 bond scission, provides convenient access to a highly functionalized and versatile cyclohexenoid building block which has been further elaborated to a range of cyclohexitols such as, conduritol E, allo-inositol and gabos