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A nonsense mutation (Arg-196-Term) in exon 6 of the human TP53 gene identified in small cell lung carcinoma

โœ Scribed by Vanessa M. Hayes; C.J.Joubert Oosthuizen; Maritha J. Kotze; Munro P. Marx; Charles H.C.M. Buys


Book ID
115638139
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
91 KB
Volume
10
Category
Article
ISSN
0890-8508

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## Abstract A series of 121 human breast tumors was screened for point mutations in exons 5 through 8 of the p53 gene, by SSCP analysis. On the same tumor samples, the Sโ€phase index (SPI) was determined by the incorporation of BUdR in fresh tissue. p53 mutations were observed in 29% of the cases. T