In primary human breast carcinomas mutat
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Giorgio R. Merlo; Amelia Bernardi; Francesca Diella; Tiziana Venesio; Alberto P.
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Article
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1993
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John Wiley and Sons
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French
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## Abstract A series of 121 human breast tumors was screened for point mutations in exons 5 through 8 of the p53 gene, by SSCP analysis. On the same tumor samples, the Sโphase index (SPI) was determined by the incorporation of BUdR in fresh tissue. p53 mutations were observed in 29% of the cases. T