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A Non-peptidic photoactivatable antagonist for mapping the antagonist binding site of the tachykinin NK2 receptor

✍ Scribed by Ian D. Kersey; Nirmala Bhogal; Dan Donnelly; Colin W.G. Fishwick; John B.C. Findlay; Peter Ward

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
207 KB
Volume
6
Category
Article
ISSN
0960-894X

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## Abstract The airways' pharmacology of DNK333 ((1R,3R,2E)‐N‐[3,4‐dichlorobenzyl)]‐4‐[(hexahydro‐2‐oxo‐1H‐azepin‐3‐yl)amino]‐N‐methyl‐3,5bis(trifluoromethyl) benzamide), a potent and selective dual NK~1~/NK~2~ neurokinin receptor antagonist is described in the present paper. DNK333 bound with high