A non-Mendelian factor, [eta+], causes lethality of yeast omnipotent-suppressor strains

✍ Scribed by Susan W. Liebman; Jamie A. All-Robyn

• Book ID: 104755131
• Publisher: Springer-Verlag
• Year: 1984
• Tongue: English
• Weight: 561 KB
• Volume: 8
• Category: Article
• ISSN: 0172-8083
• DOI: 10.1007/bf00395701

✦ Synopsis

Omnipotent suppressors cause translational ambiguity and have been associated with poor growth and inviability. We now report that a non-Mendelian element, [eta+], causes this inviability. In [eta-] strains the suppressors are not inviable. The [eta + ] genetic element segregates to about 70% of the meiotic progeny, although almost all of the spores probably have the [eta + ] phenotype for the first few divisions. Growth on 5 mM guanidine hydrochloride efficiently causes [eta + ] strains to become [eta-]. The [eta +] factor has many similarities with the previously described [psi + ] factor (Cox 1965(Cox , 1971)). However, [eta + ] and [psi + ] differ in their patterns of inheritance, and by the fact that [psi + ] affects ochre specific and not omnipotent suppressors, while the converse is true of [eta + ].