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A non-IGF binding mutant of IGFBP-3 modulates cell function in breast epithelial cells

✍ Scribed by C.M Perks; C McCaig; J.B Clarke; D.R Clemmons; J.M.P Holly

Book ID
117052042
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
318 KB
Volume
294
Category
Article
ISSN
0006-291X

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✍ Constance J. Grill; Wendie S. Cohick πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 215 KB πŸ‘ 2 views

IGF-I is mitogenic for the bovine mammary epithelial cell line MAC-T. In addition, IGF-I specifically upregulates IGFBP-3 synthesis in these cells. To investigate this effect on cell growth and IGF-I responsiveness, cell lines were developed that constitutively express IGFBP-3. MAC-T cells transfect