A non-excision uvr-dependent DNA repair pathway of Escherichia coli (involvement of stress proteins)
✍ Scribed by Milena Sedliakova
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 782 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1011-1344
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✦ Synopsis
In UV-irradiated excision-proficient (uvr ÷ ) Escherichia co li, pre-induced by simultaneous pre-starvation for thymine (T) and amino acids (AAs), and/or a low UV pre-dose applied after prestarvation for AAs, pyrimidine dimer excision (PDE) is reduced without an adequate increase of UV sensitivity and UV mutagenesis. The unexcised lesions are tolerated by a putative repair pathway that is uvr dependent but does not involve excision. The process consists of PDE inhibition, which requires outer membrane protease OmpT, and subsequent pyrimidine dimer (PD) toleration, which may be mediated by interaction with a sister duplex using a number of SOS and stress-inducible proteins.