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A new versatile methodology for the synthesis of 4-halogenated-6-diethylcarbamoylpyridine-2-carboxylic acids

✍ Scribed by Anne-Sophie Chauvin; Raphaël Tripier; Jean-Claude G Bünzli

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 60 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)00392-6

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✦ Synopsis

Convenient syntheses of dipicolinic or chelidamic acid derivatives including 4-X-6-diethylcarbamoyl-pyridine-2-carboxylic acid (X=H, Cl, Br) and 4-chloro-6-(3-oxo-3-phenylpropionyl)pyridine-2-carboxylic acid methyl ester are described. These compounds are important synthons for the synthesis of non-symmetric tridentate aromatic chelating agents as well as for the design of ditopic ligands targeted for the elaboration of functional dimetallic helicates.

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