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A New Tyrosine Kinase Inhibitor from a Marine Isolate of Ulocladium botrytis and New Metabolites from the Marine Fungi Asteromyces cruciatus and Varicosporina ramulosa

✍ Scribed by Ulrich Höller; Gabriele M. König; Anthony D. Wright

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 308 KB
Volume: 1999
Category: Article
ISSN: 1434-193X
DOI: 10.1002/(sici)1099-0690(199911)1999:11<2949::aid-ejoc2949>3.0.co;2-y

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✦ Synopsis

The sponge-derived fungi Ulocladium botrytis and yielded the new metabolite (+)-2,4-dimethyl-4,5dihydrofuran-3-carbaldehyde (4) together with the known Asteromyces cruciatus, and the algal-derived fungus Varicosporina ramulosa, were isolated and extracts from compounds (3S,5R)-dimethyldihydrofuran-2-one ( 5) and tri-O-acetyl glycerol. From V. ramulosa the five macrodiolides cultures investigated for their metabolite production. Investigations of the extract of the culture of U. botrytis grahamimycin A 1 (6), colletoketol ( 7), (6R,11R,12R,14R)colletodiol (8), 9,10-dihydro-(6R,11S,12S,14R)-colletodiol (9) guided by bioassay yielded the new tyrosine kinase (p56 lck ) inhibitor ulocladol (1) together with 1-hydroxy-6-methyl-8-and 9,10-dihydro-(6R,11R,12R,14R)-colletodiol (10) together with ergosterol were obtained, 9 and 10 being new fungal (hydroxymethyl)xanthone (3), which showed antifungal activity. The extract of the culture medium of A. cruciatus metabolites.

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