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A New Type of Pyrrolidine Biosynthesis Is Involved in the Late Steps of Xenocoumacin Production in Xenorhabdus nematophila

✍ Scribed by Daniela Reimer; Eva Luxenburger; Alexander O. Brachmann; Helge B. Bode


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
313 KB
Volume
10
Category
Article
ISSN
1439-4227

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## Abstract The gene __valC__, which encodes an enzyme homologous to the 2‐__epi__‐5‐__epi__‐valiolone kinase (AcbM) of the acarbose biosynthetic pathway, was identified in the validamycin A biosynthetic gene cluster. Inactivation of __valC__ resulted in mutants that lack the ability to produce val