A new type of bradykinin B2 receptor antagonists: bradykinin analogs with N-alkyl amino acids at position 2

Global chimeric exchanges within the int

Global chimeric exchanges within the intracellular face of the bradykinin B2 receptor with corresponding angiotensin II type Ia receptor regions: Generation of fully functional hybrids showing characteristic signaling of the AT1a receptor

✍ Jun Yu; Gregory N. Prado; Linda Taylor; Andrea Piserchio; Abhas Gupta; Dale F. M 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 344 KB

## Abstract The intracellular (IC) face of the G‐protein coupled receptors (GPCR), bradykinin (BK) B2 and angiotensin (AT) 1a, is similar in sequence homology and in size. Both receptors are known to link to Gαi and Gαq but differ markedly in a number of physiologic actions, particularly with respe