A new thymine free synthesis of the anti-AIDS drug d4T via regio/stereo controlled β-elimination of bromoacetates

✍ Scribed by Bang-Chi Chen; Sandra L. Quinlan; J. Gregory Reid; Richard H. Spector

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 192 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)01084-8

✦ Synopsis

The anti-AIDS drug d4T was prepared without contamination of the nucleoside bond cleaved by-product thymine from the readily available ribonucleoside 5-methyluridine (1). This was accomplished by using a new strategy which involved a regio/stereo controlled #-elimination of trans-bromoacetates 6.