✦ LIBER ✦
A new thiol protecting trimethylacetamidomethyl group. Synthesis of a new porcine brain natriuretic peptide using the S-trimethylacetamidomethyl-cysteine
✍ Scribed by Yoshiaki Kiso; Makoto Yoshida; Tooru Kimura; Yoichi Fujiwara; Masanori Shimokura
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 327 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The S-trimethylacetamidomethyl-cysteine [Cys(Tacm)], which can be easily prepared without any serious side reaction, was stable to acidic and alkaline conditions, and readily converted to cystine by iodine oxidation. This new Cys(Tacm) derivative is successfully applied to the conventional solution synthesis of a new porcine brain natriuretic pcptide.