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A new synthetic route to 2-oxazolines. The electrochemical reduction of N-(2,2-dichloroethyl)amides as a key step

✍ Scribed by Antonio Guirado; Raquel Andreu; Jesús Gálvez


Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
222 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis


A convenient new method for the synthesis of 2-oxazolines has been established involving the preparation of N-(2,2-dichloroethyl)amides followed by electrochemical reductive cyclizafions. It has been applied successfully in preparing pa'eviously unknown 4-a&ylamino-2-phenyl-2-oxazofines in fair to good yields.


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A convenient new method for the synthesis of 1-chlorophenazines has been established. The ®rst step involves an almost quantitative electrochemical reduction of 3,3,6,6-tetrachloro-1,2-cyclohexanedione 1 to 3,6,6-trichloro-2-hydroxy-2-cyclohexen-1-one 2. The reaction of 2 with aromatic 1,2-diamines