A new synthetic route to 1,25-dihydroxy-vitamin D3
β Scribed by Stephen R. Wilson; A.M. Venkatesan; C.E. Augelli-Szafran; A. Yasmin
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 230 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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An efficient synthesis of the title compound is reported based on C-l functionalization of the triazoline Diels-Alder adduct of 25-OH previtamin D3 (2). lu,25-Dihydroxy vitamin D3 (la) is considered as the most important and active natural metabolite of vitamin D 1 3 -Recently we have described a no
## Abstract 1Ξ±,25βdihydroxy vitamin D~3~ (vitamin D~3~) has an important role during osteoblast differentiation as it directly modulates the expression of key boneβrelated genes. Vitamin D~3~ binds to the vitamin D~3~ receptor (VDR), a member of the superfamily of nuclear receptors, which in turn i
1a,25-dihydroxy vitamin D3 has a major role in the regulation of the bone metabolism as it promotes the expression of key bone-related proteins in osteoblastic cells. In recent years it has become increasingly evident that in addition to its well-established genomic actions, 1a,25-dihydroxy vitamin