The nitro group in tertiary or secondary aliphatic nitro compounds is replaced by hydrogen or deuterium on treatment with tributyltin hydride or tributyltin deuteride, respectively.
A new synthetic method of nitro sugars
โ Scribed by Tetsuyoshi Takamoto; Rokuro Sudoh; Toshio Nakagawa
- Publisher
- Elsevier Science
- Year
- 1971
- Tongue
- French
- Weight
- 182 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
Recently, the first member of nitro sugars has been encountered in Nature, i.e. evernitrose 1) , obtained as a hvdrolytic fragment from everninomicin antibiotics. It has been found in our laboratory 2) , on the other hand, that some purine and pvrimidine bases can be introduced with surprising ease in the C-2 position of 3-deoxy-7-nitrosrlucopyranosides to afford a new type of
๐ SIMILAR VOLUMES
Nitrosoureas are an important class of antitumor agents'. Analogues of streptozotocin (N-nitroso-N-methyl urea of 2-amino-2-deoxy-D-glucose)2\*3 have been described and many other nitrosoureido sugars have been prepared4. Nitrosoureido sugars can be obtained easily by aqueous nitrosation of ureido s