๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

A new synthetic method of 3-acyltetronic acid derivatives and its application to the synthesis of isoaspertetronin a (isogregatin A)

โœ Scribed by Kei Takeda; Hiroko Kubo; Toru Koizumi; Eiichi Yoshii

Publisher
Elsevier Science
Year
1982
Tongue
French
Weight
249 KB
Volume
23
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

โœฆ Synopsis

A new synthetic method of 3-acyltetronic acid derivatives from the corresponding 3bromo compound via lithiation with n-BuLi followed. either by acylation with acid chloride or better by first reacting with aldehyde and then subsequent oxidation with active MnO2 is described.

A revised structure ,l$ for aspertetronin A(gregatin A) was presented based on the synthesis of the proposed structure $ and spectral comparison of a model compound l.l with the natural product.

In our recent program directed towards the total synthesis of those antibiotics bearing 3-

๐Ÿ“œ SIMILAR VOLUMES

A new synthetic equivalent of the glutam
A new synthetic equivalent of the glutamic acid ฮณ-anion and its application to the synthesis of S-(+)-ฮณ-carboxyglutamic acid.
โœ Michael R. Attwood; Maria G. Carr; Steven Jordan ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 128 KB

Protected S-pyroglutamic acid can be deprotonated specifically at the y-position. The resulting enolate can be converted into y-carboxyglutamic acid in optically pure form. The naturally occurring aminoacid r\_carboxyglutamtc acid (1; Gla) is a constituent of prothrombin and other proteins.1 The nat