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A New Synthetic Approach to the C Ring of Known as Well as Novel Bryostatin Analogues

✍ Scribed by Wender, Paul A.; Koehler, Michael F. T.; Sendzik, Martin


Book ID
121322854
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
90 KB
Volume
5
Category
Article
ISSN
1523-7060

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## Abstract Herein, we report the synthesis of novel ring‐expanded bryostatin analogues. By carefully modifying the substrate, a selective and high‐yielding Ru‐catalyzed tandem enyne coupling/Michael addition was employed to construct the northern fragment. Ring‐closing metathesis was utilized to f