A one-step synthesis of ethyl 2,3-dihydronaphtho[1,2-b]furan-2-carboxylate and/or ethyl 4'-oxospiro[cyclopropane-1,1'(4'H)-naphthalene]-2'-carboxylate derivatives 2 and 3, respectively, from substituted naphthalen-1-ols and ethyl 2,3-dibromopropanoate is described (Scheme 1). Compounds 2 were easily
A New Synthetic Approach to 4-Hydroxybenzofuran and 5-Hydroxychroman Derivatives
✍ Scribed by R. Verhé; N. Schamp; L. De Buyck; N. De Kimpe; M. Sadones
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2010
- Weight
- 368 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0037-9646
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In this article, a new synthetic approach to a 1,4,2-oxazaphosphorinane, and to ␣-ethyl-␣-N-(hydroxyethylamino)methyl phosphonicacid and their sodium salts is described. The title compounds were characterized by NMR and FAB spectroscopy.
A new, three-stage synthesis of 1,3,5-triamino-2,4,6-trinitrobenzene (TATB) has been developed which avoids the use of halogenated precursors or reagents. The starting material, 1,3,5trihydroxy-benzene, is converted via the sequence nitrationalkylation-amination to TATB in an overall yield of 87%. T