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A new synthesis of piperidines and pyridines and pyridines: [3+3] annulation of 2-azaallyl anions

✍ Scribed by Thomas W. Bell; Lain-Yen Hu

Book ID: 104216716
Publisher: Elsevier Science
Year: 1988
Tongue: French
Weight: 232 KB
Volume: 29
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)80617-6

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✦ Synopsis

A one-pot approach to 6-membered heterocyclic rings combines two 1,3-dipole equivalents: P-azaallyl anions (2) and iodosilane 3. The resulting a-2.6.disubstituted 4methylenepiperidines are converted in high yield to 2,4,6_trisubstituted pyridines (6) by oxidation with mercuric acetate in acetic acid.

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