A new synthesis of oligodeoxynucleoside methylphosphonates on control pore glass polymer support using phosphite approach

Polymer support oligonucleotide synthesi

Polymer support oligonucleotide synthesis 13: Rapid and efficient synthesis of oligodeoxynucleotides on porous glass support using triester approach

✍ H. Köster; A. Stumpe; A. Wolter 📂 Article 📅 1983 🏛 Elsevier Science 🌐 French ⚖ 277 KB

The rapid and efficient synthesis of d(TTTATT) and d(CATGAGGAAGT) on glass beads of controlled pore size using N-acylated 5'-O-trityldeoxynucleoside-3'-(2-chloro)-phenyl phosphates as phosphate components, capping with acetic anhydride, detritylation with ZnBr2 and 1-(mesitylene-2-sulphonyl)-3-nitro