TheN-Benzylirninederivedfrom2,3-di-O-benzyl-D-glyceraidehyde reactswithDanishefsky's diene to afford the correspondinghetero Diels-Alder adductwith a high diaatereoaelectivity. This compoundcanbe.transformed to enantiomerically pure(2R)40xopipecolicacid 01997 EIsevierScienceLtd. The piperidine ring
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A New Synthesis of N.alpha.,N.delta.-Protected N.delta.-Hydroxycycloornithine and Its Homolog from an L-Glutamic Acid Derivative
✍ Scribed by Sakamoto, Takeshi; Kikugawa, Yasuo
- Book ID
- 125516943
- Publisher
- American Chemical Society
- Year
- 1994
- Tongue
- English
- Weight
- 429 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3263
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Asymmetric Hetero Diels-Alder Reaction of N-Benzylimines Derived from ( R)-Glyceraldehyde: A New Approach to Homochiral Piperidine Building Blocks and Its Application to the Synthesis of (2R)-4-Oxopipecolic Acid. -The D-glyceraldehyde derived N-benzyl imine (I) undergoes a highly diastereoselective