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A New Synthesis of (-)-Biopterin Employing 5-Deoxy-L-ribose as a Key Intermediate

✍ Scribed by Mori, Kenji ;Kikuchi, Haruhiko

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 331 KB
Volume: 1989
Category: Article
ISSN: 0947-3440
DOI: 10.1002/jlac.1989198902102

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✦ Synopsis

Carbohydrates are important as ehiral sources in modern organic syntheses'! However, the choice of a carbohydrate for the starting material of a synthesis remains as a significant problem in view of efficiency and economy.

(-)-Biopterin (1) is one of the potent natural pterins isolated from human urine as the growth factor of Critlzidia fasciculata by Patterson ct al.''. It attracted much attention as the precursor of (6R)-tetrahydrobiopterin which was known as a coenzyme of aromatic amino acid monooxygenase '1.

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