A new synthesis of 3,5-dihydroxy-7-(1-pyrrolyl)-6-heptenoic acids, a family of HMGCoA reductase inhibitors with antifungal activity
✍ Scribed by Julia Castro; José M Coterón; M.Teresa Fraile; Silvestre Garcı́a-Ochoa; Federico Gómez de las Heras; Antonio Martı́n-Cuesta
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 123 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Tritiation of 7‐oxo‐5‐cholestene‐3β,26‐diol diacetate afforded a mixture of [5α,6α‐^3^H~2~] products which were reduced with lithium aluminum hydride to provide a mixture of [5α,6α‐^3^H~2~]‐3β, (7α and 7β), 26‐triols an 3β, 26‐diol. Oxidation with Jones reagent provided 3,7‐dioxo and 3‐
Two new natural products, N- (2-methyl-3-oxodec-8-enoyl)corresponding acid chloride, in order to acylate Meldrum's acid. Subsequent aminolysis with pyrrolidine, followed by 2-pyrroline (2) and 2-(hept-5-enyl)-3-methyl-4-oxo-6,7,8,8atetrahydro-4H-pyrrolo[2,1-b]-1,3-oxazine (3), have been methylation