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A new synthesis of 3 methoxy-17β-carboxyoestra-1,3,5(10),6,8 pentaene

✍ Scribed by D.K. Banerjee; Narain Mahishi; D. Devaprabhakara

Publisher
Elsevier Science
Year
1968
Tongue
French
Weight
145 KB
Volume
9
Category
Article
ISSN
0040-4039

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✦ Synopsis

A SYNTHESIS of 3-methoxy-176-carboxyoestra-1,3,5(lO),6,8-pentaene (I, R=Z%) was described (1) earlier by Benerjee and JohnSOn and coworkers. The recent publication (2) of Harnlk & & on the applications of 2-methyl-3-carboxycyclopentanone-2-acetic acid (II) derivatives in steroid synthesis has prompted us to report the present new synthesis of I, (R=2H), using ethyl trans-2-methyl-3-carbethoxycyclopentanone-2-acetate (IIa, RX2H5) as the starting material; the isomerlc trans-and cis-keto diacids (11s and IIb; -

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