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A New Synthesis of 2-Aryl-4-hydroxyquinolines 1

โœ Scribed by Fuson, Reynold C.; Burness, Donald M.


Book ID
120825167
Publisher
American Chemical Society
Year
1946
Tongue
English
Weight
368 KB
Volume
68
Category
Article
ISSN
0002-7863

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A convenient synthesis of 2-(F-alkyl)-4-
โœ Huang Wei-Yuan; Liu Yan-Song; Lu Long ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 673 KB

A convenient new route to 2-(F-alkyl)-4-hydroxyquinolines has been developed. In the presence of triethylamine, treatment of ethyl 2,2-dihydropolyfluoroalkanoates with aromatic amines in acetonitrile at 70 "C led to a mixture of the corresponding enamines and imines, which was cyclized in polyphosph