A new synthesis of 1,7-naphthyridine

✍ Scribed by Rosita Tan; Alfred Taurins

• Book ID: 104250178
• Publisher: Elsevier Science
• Year: 1966
• Tongue: French
• Weight: 158 KB
• Volume: 7
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)99700-x

✦ Synopsis

Bwoiwd 4 homnbar 1965; in miss4 form 25 Jan-1966) J.G. Murray and C.R. Hauser (1) synthesized 3carbethoxy-4-hydroxy-l,7-naphthyridine 'I-oxide, and N. Ikekawa (2) transformed it via 4-chloro-l,7_naphthyridine into l,7naphthyridine. We wish to report on a synthesis of 1,7-naphyridine by a different method using ethyl (3) , as a starting material. Ethyl 2-cyano-3-pyridylacetate NIi40H (60 ml) were mixed, stirred at 10' at O" for 2 days. The white crystals of 2-cyano-3-pyridylacetate (I) (22.4 g) and 28% for 5 hrs. and kept 2-cyano-3-pyridylacetamide (II) obtained were purified by chromatography and crystal-