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A New Structural Transition of Serum Albumin Dependent on the State of Cys34 : Detection by 1H-NMR Spectroscopy

✍ Scribed by John Christodoulou; Peter J. Sadler; Alan Tucker


Book ID
115130491
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
682 KB
Volume
225
Category
Article
ISSN
1432-1327

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KNI-272, a highly selective and potent HIV protease inhibitor containing allophenylnorstatine [(2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid], named Apns, has been studied in dimethylsulfoxide-d6 by NMR spectroscopy and simulated annealing calculations. 1H and 13C spectra showed the presence of two