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A New Strategy to Rapidly Evaluate Kinetics of Glucuronide Efflux by Breast Cancer Resistance Protein (BCRP/ABCG2)

✍ Scribed by Baojian Wu, Wen Jiang, Taijun Yin, Song Gao, Ming Hu


Book ID
118808006
Publisher
Springer US
Year
2012
Tongue
English
Weight
602 KB
Volume
29
Category
Article
ISSN
0724-8741

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## Abstract Breast cancer resistance protein (BCRP/ABCG2) of an ATP‐binding cassette half‐transporter confers resistance against mitoxantrone and camptothecin derivatives of topotecan and irinotecan. Novobiocin, a coumermycin antibiotic, is known to enhance anticancer drug sensitivity of cancer cel