A New Strategy for the Synthesis of Benzylic Sulfonamides: Palladium-Catalyzed Arylation and Sulfonamide Metathesis
โ Scribed by Grimm, Jonathan B.; Katcher, Matthew H.; Witter, David J.; Northrup, Alan B.
- Book ID
- 120085073
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 98 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
An efficient and chemoselective sulfonamide N-alkylation of sulfonyl ureas is described. The sulfonyl urea derivatives, prepared in situ by the addition of an amine to an arylsulfonyl isocyanate, are selectively alkylated in excellent yields under neutral and mild conditions by treatment with trialk
A new synthetic protocol has been developed for the arylation of secondary and N-alkylated amide Heck precursors by the implementation of the palladium-catalyzed intramolecular Heck reaction strategies.