A new strategy for the protection of deoxyguanosine during oligonucleotide synthesis

✍ Scribed by B.L. Gaffney; R.A. Jones

• Publisher: Elsevier Science
• Year: 1982
• Tongue: French
• Weight: 237 KB
• Volume: 23
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)87315-3

✦ Synopsis

The protection of the 6-0~0 group of deoxyguanosine with the Z-trimsthylsilylethyl (L), phenylthioethyl (A), 4-nitrophenylthioethyl (5). 4-nitrophenethyl (J), and cyanoethyl (6) groups is described. is cleaved udder mild conditions.

Each protectin

group is introduced in good yield and Compatibility with the various approaches to oligonucleotide synthesis is discussed.