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A new strategy for solid phase synthesis of a secondary amide library using sulfonamide linker via radical traceless cleavage

โœ Scribed by Juntao Luo; Wenqiang Huang


Book ID
111545351
Publisher
Springer
Year
2003
Tongue
English
Weight
210 KB
Volume
6
Category
Article
ISSN
1381-1991

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The clean and efficient cleavage of N-benzyl linked tertiary amines from a solid support (e.g. 4) by treatment with ct-chloroethyl chloroformate (ACE-CI) / methanol to yield secondary amines 7 is described. This allows the solid-phase synthetic transformation of the secondary amine 2 into 7. When th