A New Stereospecific Synthesis of 1,2,4-Trideoxy-1,4-Imino-D- Erythro -Pentitol
✍ Scribed by Malle, Birgitte Mølholm; Lundt, Inge; Furneaux, Richard H.
- Book ID
- 118042537
- Publisher
- Taylor and Francis Group
- Year
- 2000
- Tongue
- English
- Weight
- 526 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0732-8303
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The relative configuration of the stereocentres in a potential hexosaminidase inhibitor, C 14 H 20 N 2 O 3 , prepared from d-lyxonolactone, has been established using X-ray crystallographic techniques.
The treatment of 4-azido-4-deoxy-2,3:5,6-di-O-isopropylidene-D-galactose propane-1,3-diyl dithioacetal (derived from D-glucose) with mercuric chloride and mercuric oxide in aqueous acetone afforded 4-azido-4-deoxy-2,3:5,6-di-O-isopropylidene-Dgalactose. Acid-catalyzed deprotection of the azido deriv