A new, stereoselective approach to pyrrolidine-N-oxides by sequential condensation of sulfones with nitrones and reverse-cope elimination

ChemInform Abstract: A New, Stereoselect

ChemInform Abstract: A New, Stereoselective Approach to Pyrrolidine-N-oxides by Sequential Condensation of Sulfones with Nitrones and Reverse-Cope Elimination.

✍ A. R. WHEILDON; D. W. KNIGHT; M. P. LEESE 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 2 views

I) and addition of nitrones (II) results in a smooth condensation to give the unsaturated hydroxylamines (III) stereoselectively. These undergo reverse-Cope cyclizations at room temperature leading to the diastereomeric mixture of pyrrolidine-N-oxides (IV) and (V). -