A new southwestern chemistry-based ELISA for detection of aryl hydrocarbon receptor transformation: application to the screening of its receptor agonists and antagonists

Development of a liquid chromatographic/

Development of a liquid chromatographic/tandem mass spectrometric assay for a new endothelin receptor antagonist, and its application to dog plasma samples generated after simultaneous i.v. and p.o. administration of the unlabeled and deuterium-labeled forms of this antagonist

✍ B. Lausecker; G. Fischer 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 166 KB

## Abstract An assay was developed and applied to determine the bioavailability of a new endothelin receptor antagonist after simultaneous p.o. and i.v. administration of the drug and its stable isotope‐labeled analogue. The drug, its main metabolite and the stable isotope‐labeled analogues of the