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A new simple route for the synthesis of (±)-2-azetidinones starting from β-Enaminoketoesters

✍ Scribed by Carmela De Risi; Gian P. Pollini; Augusto C. Veronese; Valerio Bertolasi


Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
207 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis


13-Enaminoketoesters, obtained by metal-catalyzed reaction between alkyl acetoacetates and alkyl cyanoformates, are useful starting materials for rapid access to I~-acetyl-dehydroaspartic acid derivatives which could be transformed into (+)-2-azetidinones beating a 1-hydrox'y-ethyl substituent through suitable reductive processes.


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