A new simple and rapid dual assay for AFP and free β hCG in screening for Down syndrome
✍ Scribed by Bent Nørgaard-Pedersen; Henrik Alfthan; Jørgen Arends; Claus K. Høgdall; Severin Olesen Larsen; Kim Pettersson; Ulf-Håkan Stenman; Riitta Salonen
- Book ID
- 115091469
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 291 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0009-9163
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Published studies have reached varying conclusions as to the benefit of replacing human chorionic gonadotropin (hCG) measurements with the free -subunit of hCG (the free -subunit) for Down syndrome screening. One study reports 14 per cent higher detection for the free -subunit, while another finds a
Biochemical screening for Down syndrome (DS) is well established in the second trimester of pregnancy, but there is little information available on its value in the first trimester. This study describes our preliminary results with biochemical screening for DS in the first trimester of pregnancy in
I have studied the impact of maternal smoking on the levels of maternal serum alpha-fetoprotein (AFP) and free beta human chorionic gonadotrophin (hCG) during the second trimester in a large series (30 727) of self-reported smokers and non-smokers whose pregnancy resulted in the birth of a normal fe
Human chorionic gonadotropin (hCG) free beta-subunit levels were determined in 709 control and 13 Down syndrome urine samples from the second trimester of pregnancy. Results were normalized to urine creatinine concentration and converted to multiples of the unaffected pregnancy medium (MOM). The con