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A new route towards N-(α-methoxybenzyl)aziridines

✍ Scribed by Matthias D'hooghe; Arn Hofkens; Norbert De Kimpe

Book ID
104252899
Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
128 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

A new synthesis of N-(a-methoxyarylmethyl)-2,2-dimethylaziridines is presented. Different benzaldehydes were converted into the corresponding imines upon reaction with 2-bromo-2-methylpropylamine. Treatment of the latter imines with sodium methoxide afforded N-(a-methoxyarylmethyl)-2,2-dimethylaziridines in good yields.

📜 SIMILAR VOLUMES

Payne-like rearrangement of N-tosyl-oxir
Payne-like rearrangement of N-tosyl-oxiranemethylamines: a new route to functionalized aziridines.
✍ Jean Moulines; Patricia Charpentier; Jean-Paul Bats; Alain Nuhrich; Anne-Marie L 📂 Article 📅 1992 🏛 Elsevier Science 🌐 French ⚖ 286 KB

The reachon of N-tosyl-oxrranemerhylamrnes wth aqueous so&m hydroxzde affords N-tosyl-arlrrdlnemethonols IR exrellenr welds, through the zntramolecular epoxzde ring openrng by the nz~rogen atow of the ~osylamtnn group ## Functlonahzed azlndmes have proved to be very useful reagents III synthensl