A new route to α-hetero β-enamino esters using a mild and convenient solvent-free process assisted by focused microwave irradiation

✍ Scribed by Zohra Dahmani; Mustapha Rahmouni; Richard Brugidou; Jean Pierre Bazureau; Jack Hamelin

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 279 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01894-2

✦ Synopsis

New ct-hetero ~-enamino esters $ (X = NH0 O, S) are obtained in good to excellent yields by transamination reactions from ethyl 3-dimethylamino acrylate 2(a-e) and various volatile amines 3(a-e) using solvent-free conditions assisted by focused microwave irradiation. Most of the tz-hetero ~-enamino ester derivatives 3 present a (E)s-cis/trans conformation.