A new route to enantiomerically pure 2,5-disubstituted pyrrolidines. Total synthesis of (+)-Pyrrolidine 197B.
✍ Scribed by Robert Bloch; Cécile Brillet-Femandez; Gérard Mandville
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 396 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0957-4166
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Pyrrolidines 1 and 2 are obtained from D-Mannitol, giving good total yields and in an enantiomerically pure form. Some commentS and studies regarding pyrrolidine ring closure (key step) are also qorted. Over the last few years, interest in pyrrolidine-type derivatives has grown considerably, from b
We describe the photoinduced addition of methanol to 5(S)-5-triisopropylsiloxymethyi--N-boc-dihydropyrrole-2(SH)-one to produce 5(S)-5-triisopropylsiloxymethyl-4( S)-hydroxymethylpyrrolidine-2-one, and conversion of this into a variety of 4(S), 5(S)-pyrrolidine-2-ones. Photoinduced addition of metha