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A new route to acyclic nucleosides via palladium-mediated allylic alkylation and cross-metathesis

✍ Scribed by Franck Amblard; Steven P. Nolan; Isabelle Gillaizeau; Luigi A. Agrofoglio


Book ID
108284805
Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
166 KB
Volume
44
Category
Article
ISSN
0040-4039

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Phosphine-Free Palladium-Catalyzed Allen
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## Abstract **Free to decide**: Various 4‐(α‐styryl) γ‐lactams are synthesized in 61–88 % yield by a phosphine‐free palladium‐catalyzed carbopalladation/allylic alkylation domino sequence (see scheme). The cyclization is totally regio‐ and diastereoselective in favor of the 3,4‐__trans__‐disubstitu