A new route to 1-oxygenated carbazoles. Synthesis of murrayafoline-a
โ Scribed by Tracey Martin; Christopher J. Moody
- Book ID
- 104229093
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 113 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
l-Oxygenated carbazoles are prepared in four steps from indole-2-carboxylates by Claisen condensation with butyrolactones, followed by hydrolysis with concomitant decarboxylation, oxidation, and ring closure (Scheme 2); the route is applied to the synthesis of the carbazole alkaloid, murrayafoline-A.
๐ SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract A new method for the synthesis of steroids with oxygenated side chains starting from C~22~ steroids is described. Rieke copper, obtained by reduction of lithium 2โthienylcyanocuprate 4 with lithium naphthalenide at โ78ยฐC or โ100ยฐC, reacts with the 22โbromosteroids 1a, 2, 14 to afford th