A new rhenanite (β-NaCaPO4) and hydroxyapatite biphasic biomaterial for skeletal repair
✍ Scribed by Sahil Jalota; Sarit B. Bhaduri; A. Cuneyt Tas
- Book ID
- 102873955
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 901 KB
- Volume
- 80B
- Category
- Article
- ISSN
- 1552-4973
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✦ Synopsis
Abstract
Biphasic β‐rhenanite (β‐NaCaPO~4~)–hydroxyapatite (Ca~10~(PO~4~)~6~(OH)~2~) biomaterials were prepared by using a one‐pot, solution‐based synthesis procedure at the physiological pH of 7.4, followed by low‐temperature (300–600°C) calcination in air for 6 h. Calcination was for the sole purpose of crystallization. An aqueous solution of Ca(NO~3~)~2~· 4H~2~O was rapidly added to a solution of Na~2~HPO~4~ and NaHCO~3~, followed by immediate removal of gel‐like, poorly‐crystallized precursor precipitates from the mother liquors of pH 7.4. Freeze‐dried precursors were found to be nanosize with an average particle size of 45 nm and a surface area of 128 m^2^/g. Upon calcination in air, precursor powders crystallized into biphasic (60% HA–40% rhenanite) biomaterials, while retaining their submicron particle sizes and high surface areas. β‐rhenanite is a high solubility sodium calcium phosphate phase. Samples were characterized by XRD, FTIR, SEM, TEM, ICP‐AES, TG, DTA, DSC, and surface area measurements. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007