A new preparation of trimethylsilyl ethers

✍ Scribed by Harold W. Pinnick; Bolkrishna S. Bal; Nordin H. Lajis

• Publisher: Elsevier Science
• Year: 1978
• Tongue: French
• Weight: 106 KB
• Volume: 19
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)95196-2

✦ Synopsis

We wish to report a new method for the prepamtion of trimethylsilyl (TMS) ethers frcm alcohols under mildly acidic conditions. This compliments the most common procedure for the prepamtion of this popular protecting group which uses TA4.S chloride and a base like triethylamine.

2,3

Our approach is based on the stmtegy outlined in equation 1. Thus, pratonation of bistri-H H