A new preparation of substituted 4H-1-benzothiopyran-4-ones from c(α)N-benzoylhydrazones or c(α)N-carboalkoxyhydrazones and methyl thiosalicylate
✍ Scribed by Kristen L. French; April J. Angel; Angela R. Williams; Douglas R. Hurst; Charles F. Beam
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1998
- Tongue
- English
- Weight
- 311 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0022-152X
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## Abstract C(α)‐Carboxylic acid esters were treated with excess lithium diisopropylamide, condensed with methyl salicylates or methyl thiosalicylate, followed by acid cyclization to either 4‐hydroxy‐3‐substituted, 2__H__‐1‐benzopyran‐2‐ones (coumarins), or 2__H__‐1‐benzothiopyran‐2‐ones (thiocouma
## Abstract magnified image A variety of substituted spiro(benzoisothiazole‐pyrazoles) have been prepared by the condensation of dilithiated __C__(α),__N__‐carboalkoxyhydrazones with lithiated methyl 2‐(aminosulfonyl)benzoate followed by the cyclization of intermediates with acetic anhydride, whic
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